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Colony Name |
FUMOZ-R |
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Species |
Anopheles funestus |
Country of Origin |
Mozambique |
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Liverpool Colony established (year) |
2013 |
Phenotypic characteristics |
Resistant to pyrethroids and carbamates, susceptible to organophosphates |
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Source of colonisation |
Originally colonised from southern Mozambique in 2000 (NICD South Africa). Provided to LITE by Bayer Crop Science |
Selection Procedur |
Adults selected with 1hour exposure to 0.05% deltamethrin
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Genotypic characteristics |
CYP6P9a and CYP6P9b PBO-Permethrin synergism: Significant (P < 0.001) increase in mortality (from 74% to 99%) Note: Species I.D = SS. |
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Profiling Data 24 hour % mortality after 1hour exposure to Discriminating Dose |
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Relevant Publications |
Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus.Tchouakui M, Riveron Miranda J, Mugenzi LMJ, Djonabaye D, Wondji MJ, Tchoupo M, Tchapga W, Njiokou F, Wondji CS.Heredity (Edinb). 2020 May;124(5):621-632. doi: 10.1038/s41437-020-0304-1. Epub 2020 Mar 10.PMID: 32157181 Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus.Irving H, Riveron JM, Ibrahim SS, Lobo NF, Wondji CS.Heredity (Edinb). 2012 Dec;109(6):383-92. doi: 10.1038/hdy.2012.53. Epub 2012 Sep 5. Mapping a quantitative trait locus (QTL) conferring pyrethroid resistance in the African malaria vector Anopheles funestus.Wondji CS, Morgan J, Coetzee M, Hunt RH, Steen K, Black WC 4th, Hemingway J, Ranson H.BMC Genomics. 2007 Jan 29;8:34. doi: 10.1186/1471-2164-8-34. Pyrethroid resistance in an Anopheles funestus population from Uganda.Morgan JC, Irving H, Okedi LM, Steven A, Wondji CS.PLoS One. 2010 Jul 29;5(7):e11872. doi: 10.1371/journal.pone.0011872.
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